Author

L. A. Denson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

S. Kugathasan· 2 shared A. F. Rosenberg· 1 shared A. Waddell· 1 shared B. A. Steere· 1 shared C. O. Elson· 1 shared C. Potter· 1 shared C. V. Arancibia-Carcamo· 1 shared D. Aschenbrenner· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersImmunology

S. Kugathasan

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Author profile →

3 papers

Recent·Most cited

Crohn's patients and healthy infants share immunodominant B cell response to commensal flagellin peptide epitopes

Q. Zhao, L. W. Duck, J. T. Killian, A. F. Rosenberg, P. J. Mannon, R. G. King, L. A. Denson, S. Kugathasan, E. N. Janoff, M. C. Jenmalm, C. O. Elson

The paper identifies a shared B cell response to a conserved flagellin epitope in Crohn's disease patients and healthy infants, suggesting a potential early failure of homeostatic immunity.

bioRxiv · Aug 8, 2023Immunology

Microbiota epigenetically direct tuft cell differentiation to control type 2 immunity

E. M. Eshleman, T. Rice, C. Potter, A. Waddell, S. Hashimoto-Hill, V. Woo, S. Field, L. Engleman, M. A. Schumacher, M. R. Frey, L. A. Denson, F. D. Finkelman, T. Alenghat

This study shows that butyrate-producing bacteria epigenetically control tuft cell differentiation via HDAC3, influencing type 2 immunity and helminth responses.

bioRxiv · Mar 2, 2023Immunology

Systems-level analysis of monocyte responses in inflammatory bowel disease identifies IL-10 and IL-1 cytokine networks that regulate IL-23

D. Aschenbrenner, M. Quaranta, S. Banerjee, N. Ilott, J. Jansen, B. A. Steere, Y.-H. Chen, S. Ho, K. Cox, Oxford IBD Cohort Investigators, C. V. Arancibia-Carcamo, M. Coles, E. Gaffney, S. Travis, L. A. Denson, , H. H. Uhlig

The paper identifies IL-10 and IL-1 cytokine networks that regulate IL-23 production in monocytes, distinguishing homeostatic from hyper-inflammatory IL-23 production in inflammatory bowel disease.

bioRxiv · Jan 31, 2020 · PreprintImmunology