Author

B. Constantinides

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Evolutionary Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Research Focus:gene regulatory network inference· 3 Organism:mouse· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2

Frequent Co-Authors

M. J. O'Connell· 3 shared D. Wang· 2 shared H. Tinning· 2 shared N. Forde· 2 shared A. Amini· 1 shared A. Dijokaite-Guraliuc· 1 shared A. G. Sotiropoulos· 1 shared A. J. Mathers· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersEvolutionary Biology

M. J. O'Connell

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Author profile →

6 papers

Recent·Most cited

Bursts of novel composite gene families at major nodes in animal evolution

P. O. Mulhair, R. J. Moran, J. s. Pathmanathan, D. Sussfeld, C. J. Creevey, K. Siu-Ting, F. J. Whelan, D. Pisani, B. Constantinides, E. Pelletier, p. lopez, E. Bapteste, J. O. McInerney, M. J. O'Connell

The paper identifies composite gene families in animals, showing they emerge abruptly at major evolutionary nodes and are independently evolved in multiple clades.

bioRxiv · Jul 10, 2023 · PreprintEvolutionary Biology

Further antibody escape by Omicron BA.4 and BA.5 from vaccine and BA.1 serum

A. Tuekprakhon, J. Huo, R. Nutalai, A. Dijokaite-Guraliuc, D. Zhou, H. M. Ginn, M. Sekvaraj, C. Liu, A. J. Mentzer, P. Supasa, H. M. E. Duyvesteyn, R. Das, D. Skelly, T. G. Ritter, A. Amini, , G. R. Screaton

This study shows that BA.4 and BA.5 variants are more resistant to neutralization by vaccine and BA.1 immune sera compared to BA.1 and BA.2.

bioRxiv · May 21, 2022 · PreprintMicrobiology

A burst of regulatory and protein innovation at the origin of placental mammals drove the emergence of placenta and underpins divergent early pregnancy strategies in modern mammals.

A. S. Taylor, H. Tinning, V. Ovchinnikov, W. Smith, A. L. Pullinger, R. A. Sutton, B. Constantinides, D. Wang, N. Forde, M. J. O'Connell

The paper identifies a core miRNA network that originated in placental mammals and explains the evolution of placenta and diverse pregnancy strategies.

bioRxiv · Jul 22, 2021 · PreprintEvolutionary Biology

Bacteriophage deficiency characterizes respiratory virome dysbiosis in childhood asthma

S. Megremis, B. Constantinides, P. Xepapadaki, C. Bachert, S. Neurath-Finotto, T. Jartti, M. L. Kowalski, A. G. Sotiropoulos, A. Tapinos, T. Vuorinen, E. Andreakos, D. L. Robertson, N. G. Papadopoulos

The paper examines the respiratory virome in preschool children with and without asthma during asymptomatic periods, finding bacteriophage deficiency and increased eukaryotic viral presence in asthmatic children.

bioRxiv · Aug 4, 2020Microbiology

Multi-omic surveillance of Escherichia coli and Klebsiella spp. in hospital sink drains and patients

B. Constantinides, K. K. Chau, T. P. Quan, G. Rodger, M. Andersson, K. J. Jeffery, S. Lipworth, S. Gweon, A. Peniket, G. Pike, J. Millo, M. Byukusenge, M. Holdaway, C. Gibbons, A. J. Mathers, , N. Stoesser

The paper shows hospital sink drains are colonized by diverse E. coli and Klebsiella strains, including resistant ones, and may contribute to patient infections.

Microbial Genomics · Jul 1, 2020Peer-reviewedMicrobiology

The role of CAPG in molecular communication between the embryo and the uterine endometrium: Is its function conserved in species with different implantation strategies?

H. Tinning, A. Taylor, D. Wang, B. Constantinides, R. Sutton, G. Oikonomou, M. A. Velazquez, P. Thompson, A. Treumann, M. J. O'Connell, N. Forde

This study shows that CAPG, a conserved protein, induces transcriptional changes in endometrial cells of humans and cattle, potentially aiding implantation across species with different implantation strategies.

bioRxiv · Feb 19, 2020Physiology