Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
7 papers
Recent·Most cited
T. Mehlman, H. M. Ginn, D. A. Keedy
The paper reanalyzes crystallographic data to identify new ligand-bound states of PTP1B, revealing hidden binding sites and allosteric effects.
bioRxiv · Jan 5, 2024Biophysics
J. A. Hill, Y. R. Nyathi, S. Horrell, D. von Stetten, D. Axford, R. L. Owen, G. S. Beddard, A. R. Pearson, H. M. Ginn, B. A. Yorke
The paper identifies a UV-induced redox switch mechanism in human gamma-D crystallin that may rescue oxidative damage.
bioRxiv · Aug 25, 2023Biochemistry
This paper introduces RoPE, a torsion-angle based method to map and visualize protein conformational space, showing it correlates with temperature, resolution, and reaction coordinate better than atomic coordinates.
bioRxiv · Aug 4, 2022Biochemistry
A. Tuekprakhon, J. Huo, R. Nutalai, A. Dijokaite-Guraliuc, D. Zhou, H. M. Ginn, M. Sekvaraj, C. Liu, A. J. Mentzer, P. Supasa, H. M. E. Duyvesteyn, R. Das, D. Skelly, T. G. Ritter, A. Amini, , G. R. Screaton
This study shows that BA.4 and BA.5 variants are more resistant to neutralization by vaccine and BA.1 immune sera compared to BA.1 and BA.2.
bioRxiv · May 21, 2022 · PreprintMicrobiology
E. C. Schulz, A. Prester, D. von Stetten, G. Gore, C. E. Hatton, K. Bartels, J.-P. Leimkohl, H. Schikora, H. M. Ginn, F. Tellkamp, P. Mehrabi
The paper introduces an environmental enclosure for serial crystallography to study enzyme kinetics across temperatures, showing temperature-dependent modulation in two enzymes.
bioRxiv · Nov 7, 2021Biophysics
W. - Dejnirattisai, D. - Zhou, P. - Supasa, C. - Liu, A. J. Mentzer, H. M. Ginn, Y. - Zhao, H. M. E. Duyvesteyn, A. Tuekprakhon, R. Nutalai, B. - Wang, G. C. Paesen, C. - Lopez-Camacho, J. - Slon-Campos, T. Walter, , Barne
This study compares antibody resistance of SARS-CoV-2 variants P.1, B.1.351, and B.1.1.7, finding P.1 is less resistant to antibodies despite similar ACE2 binding mutations.
bioRxiv · Mar 12, 2021Microbiology
J. Huo, Y. Zhao, J. Ren, D. Zhou, H. M. E. Duyvesteyn, H. M. Ginn, L. Carrique, T. Malinauskas, R. R. Ruza, P. N. Shah, T. K. Tan, P. Rijal, N. Coombes, K. Bewley, J. Radecke, , D. I. Stuart
This paper identifies CR3022 as a monoclonal antibody that neutralizes SARS-CoV-2 by destroying its prefusion Spike conformation, suggesting therapeutic potential.
Cell Host & Microbe · Sep 1, 2020Peer-reviewedMicrobiology