A. Amini

Evolution of a biological thermocouple by adaptation of cytochrome c oxidase in asubterrestrial metazoan

This study identifies a temperature-sensing adaptation in the cytochrome c oxidase of the Devil Worm, Halicephalobus mephisto, showing how evolutionary changes in mitochondrial function enable temperature-dependent metabolic regulation.

Further antibody escape by Omicron BA.4 and BA.5 from vaccine and BA.1 serum

This study shows that BA.4 and BA.5 variants are more resistant to neutralization by vaccine and BA.1 immune sera compared to BA.1 and BA.2.

Human MAIT cells show clonal diversity but transcriptional and functional homogeneity

The paper analyzes MAIT cell clonal diversity and functional responses using single-cell RNA-seq and fRNA-seq, finding high TCR diversity and tissue-specific functional patterns.

Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

This study shows that Omicron-B.1.1.529 has extensive mutations in Spike that reduce neutralization by antibodies from vaccinated and previously infected individuals, and escape most monoclonal antibodies.

Pattern-based Contractility Screening (PaCS), a reference-free traction force microscopy methodology, reveals contractile differences in breast cancer cells

PaCS measures cell contractile work in real-time without complex substrate fabrication, showing higher contractility in metastatic breast cancer cells compared to non-invasive cells.

Human intestinal tissue-resident memory CD8+ T cells comprise transcriptionally and functionally distinct subsets

This study identifies transcriptionally and functionally distinct subsets of human intestinal TRM cells, with β2-integrin marking a unique CD8+ TRM population.

Activation of MAIT cells plays a critical role in viral vector vaccine immunogenicity

This study shows that MAIT cell activation is essential for the immunogenicity of adenovirus vector vaccines, as it drives HCV-specific CD8 T cell responses.