Constitutive Expression of the Progesterone Receptor Isoforms Promotes Hormone-Dependent Development of Ovarian Neoplasms
M. Wetendorf, R. Li, S.-P. Wu, J. Liu, C. J. Creighton, T. Wang, K. S. Janardhan, C. J. Wilson, R. B. Lanz, B. D. Murphy, J. P. Lydon, F. J. DeMayo
This study shows that overexpression of PGRB promotes ovarian tumor development in mice, while PGRA reduces tumor frequency, highlighting the role of PGR isoforms in hormone-dependent neoplasia.
bioRxiv · Oct 24, 2019Cancer Biology