Author

C. J. Creighton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2

Frequent Co-Authors

F. J. DeMayo· 2 shared J. P. Lydon· 2 shared A. M. Buechlein· 1 shared A. Pedroza· 1 shared A. Rajan· 1 shared B. D. Murphy· 1 shared B. Dong· 1 shared C. J. Wilson· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersCancer Biology

F. J. DeMayo

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5 papers

Recent·Most cited

Longitudinal host transcriptional responses to SARS-CoV-2 infection in adults with extremely high viral load

V. Avadhanula, C. J. Creighton, L. Ferlic-Stark, R. Sucgang, Y. Zhang, D. Nagaraj, E. G. Nicholson, A. Rajan, V. K. Menon, H. Doddapaneni, D. M. Muzny, G. A. Metcalf, S. J. J. Cregeen, K. L. Hoffman, R. A. Gibbs, , P. A. Piedra

The paper examines longitudinal transcriptional responses to SARS-CoV-2 infection in adults with varying viral loads, identifying gene expression patterns and host responses over time.

bioRxiv · May 24, 2023Microbiology

Non-canonical Wnt/Ror2 signaling regulates cell-matrix crosstalk to prompt directional tumor cell invasion and dissemination in breast cancer

H. Si, N. Zhao, A. Pedroza, J. Rosen, C. J. Creighton, K. Roarty

This study shows Ror2 regulates tumor cell-ECM interactions in breast cancer, promoting invasion through integrin and FAK pathways.

bioRxiv · May 15, 2021Cancer Biology

Oncogenic Activation of AKT by MAPK6

Q. Cai, W. Wang, B. Dong, W. Zhou, T. Shen, D. D. Moore, C. J. Creighton, F. Yang

This study shows that MAPK6 activates AKT to promote cancer, leading to oncogenic outcomes and poor patient survival in multiple cancers.

bioRxiv · Sep 23, 2020Cancer Biology

Pten and Dicer1 loss causes poorly-differentiated endometrial adenocarcinoma in mice

X. Wang, J. Wendel, R. E. Emerson, R. R. Broaddus, C. J. Creighton, D. Rusch, A. M. Buechlein, F. J. DeMayo, J. P. Lydon, S. Hawkins

This paper shows that deleting Pten and Dicer1 in mice leads to poorly-differentiated endometrial adenocarcinoma with molecular features similar to human DICER1-mutant cancers.

bioRxiv · Mar 12, 2020 · PreprintCancer Biology

Constitutive Expression of the Progesterone Receptor Isoforms Promotes Hormone-Dependent Development of Ovarian Neoplasms

M. Wetendorf, R. Li, S.-P. Wu, J. Liu, C. J. Creighton, T. Wang, K. S. Janardhan, C. J. Wilson, R. B. Lanz, B. D. Murphy, J. P. Lydon, F. J. DeMayo

This study shows that overexpression of PGRB promotes ovarian tumor development in mice, while PGRA reduces tumor frequency, highlighting the role of PGR isoforms in hormone-dependent neoplasia.

bioRxiv · Oct 24, 2019Cancer Biology