Non-canonical roles of caspase-4 and caspase-5 in heme driven- IL-1β release and cell death
B. E. Bolivar, A. N. Brown, B. A. Rohrman, C. I. Charendoff, V. Yazdani, J. D. Belcher, G. M. Vercellotti, J. M. Flanagan, L. Bouchier-Hayes
This paper identifies extracellular heme as a DAMP that activates caspase-1, caspase-4, and caspase-5, leading to IL-1β release and cell death in macrophages, with caspase-4 playing a primary role in cell death.
bioRxiv · Feb 28, 2020Immunology