Author

J. M. Flanagan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Cancer Biology· 2 Microbiology· 2 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 8 Organism:human· 6 Research Focus:cell signaling & trafficking· 4 Assay:proteomics· 3 Assay:DNA methylation· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

M. C. Bewley· 3 shared C. I. Charendoff· 2 shared F. Tian· 2 shared G. S. Lambert· 2 shared G. Wang· 2 shared H.-G. Wang· 2 shared L. Bouchier-Hayes· 2 shared L. J. Parent· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

M. C. Bewley

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

The Rous sarcoma virus Gag polyprotein forms biomolecular condensates driven by intrinsically-disordered regions

R. K. Maldonado, B. L. Rice, G. S. Lambert, M. Sudol, J. M. Flanagan, L. J. Parent

This study identifies that the Rous sarcoma virus Gag polyprotein forms biomolecular condensates driven by intrinsically disordered regions, which are involved in viral assembly.

Journal of Molecular Biology · Aug 1, 2023Peer-reviewedMicrobiology

Caspase-2 is essential for proliferation and self-renewal of nucleophosmin-mutated acute myeloid leukemia.

D. Sakthivel, A. N. Brown-Suedel, F. Keane, S. Huang, K. Mc Sherry, C. I. Charendoff, K. P. Dunne, D. J. Robichaux, B. Le, C. S. Shin, A. F. Carisey, J. M. Flanagan, L. Bouchier-Hayes

This study shows caspase-2 is essential for proliferation and self-renewal of NPM1-mutated AML cells, suggesting it as a potential therapeutic target.

bioRxiv · May 29, 2023Cancer Biology

Influence of HIV-1 genomic RNA on the formation of Gagbiomolecular condensates

A. Monette, M. Niu, R. K. Maldonado, J. Chang, G. S. Lambert, J. M. Flanagan, A. W. Cochrane, L. J. Parent, A. Mouland

This study investigates how HIV-1 genomic RNA influences Gag biomolecular condensate formation and size, revealing salt-dependent effects of mutations and compartment-specific differences in host factors.

bioRxiv · Feb 23, 2023Microbiology

Translating Membrane Geometry into Protein Function: Multifaceted Membrane Interactions of Human Atg3 Promote LC3-Phosphatidylethanolamine Conjugation during Autophagy

Y. Ye, E. R. Tyndall, V. Bui, M. C. Bewley, G. Wang, X. P. Hong, Y. Shen, J. M. Flanagan, H.-G. Wang, F. Tian

This study determines the solution structure of human Atg3 and shows how its dynamic regions and membrane interactions facilitate LC3-PE conjugation during autophagy.

bioRxiv · Dec 23, 2022 · PreprintBiochemistry

Curvature Sensing and Membrane Remodeling of the VPS37A N-terminal Domain during Autophagy

Y. Ye, X. Liang, G. Wang, M. C. Bewley, X. Liu, J. M. Flanagan, H.-G. Wang, Y. Takahashi, F. Tian

This study identifies two hydrophobic motifs in VPS37A that bind curved membranes, essential for autophagosome biogenesis.

bioRxiv · Nov 1, 2022 · PreprintBiochemistry

Chromatin accessibility changes at intergenic regions associates with ovarian cancer drug resistance

J. Gallon, E. Loomis, E. Curry, N. Martin, L. Brody, I. Garner, R. Brown, J. M. Flanagan

The paper examines chromatin accessibility changes in ovarian cancer cell lines resistant to platinum-based chemotherapy, finding intergenic region alterations linked to drug resistance and Pt-adduct distribution.

bioRxiv · Feb 24, 2021Cancer Biology

Molecular architecture and domain arrangement of the placental malaria protein VAR2CSA suggests a model for receptor binding

M. C. Bewley, L. Gautam, D. C. Gowda, J. M. Flanagan

The paper determines the structural architecture of VAR2CSA, revealing two CSA-binding pores that suggest a model for receptor binding in placental malaria.

bioRxiv · Apr 16, 2020Biophysics

Non-canonical roles of caspase-4 and caspase-5 in heme driven- IL-1β release and cell death

B. E. Bolivar, A. N. Brown, B. A. Rohrman, C. I. Charendoff, V. Yazdani, J. D. Belcher, G. M. Vercellotti, J. M. Flanagan, L. Bouchier-Hayes

This paper identifies extracellular heme as a DAMP that activates caspase-1, caspase-4, and caspase-5, leading to IL-1β release and cell death in macrophages, with caspase-4 playing a primary role in cell death.

bioRxiv · Feb 28, 2020Immunology