Author

L. Bouchier-Hayes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C. I. Charendoff· 3 shared A. F. Carisey· 2 shared J. M. Flanagan· 2 shared A. Boice· 1 shared A. N. Brown· 1 shared A. N. Brown-Suedel· 1 shared B. A. Rohrman· 1 shared B. E. Bolivar· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCancer Biology

C. I. Charendoff

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Caspase-2 is essential for proliferation and self-renewal of nucleophosmin-mutated acute myeloid leukemia.

D. Sakthivel, A. N. Brown-Suedel, F. Keane, S. Huang, K. Mc Sherry, C. I. Charendoff, K. P. Dunne, D. J. Robichaux, B. Le, C. S. Shin, A. F. Carisey, J. M. Flanagan, L. Bouchier-Hayes

This study shows caspase-2 is essential for proliferation and self-renewal of NPM1-mutated AML cells, suggesting it as a potential therapeutic target.

bioRxiv · May 29, 2023Cancer Biology

Caspase-2 regulates S-phase cell cycle events to protect from DNA damage accumulation independent of apoptosis

A. Boice, R. K. Pandita, K. Lopez, M. J. Pourpak, C. I. Charendoff, V. K. Charaka, A. F. Carisey, T. K. Pandita, L. Bouchier-Hayes

This study shows caspase-2 regulates S-phase cell cycle events to reduce DNA damage accumulation without relying on its pro-apoptotic function.

bioRxiv · Mar 30, 2021Cell Biology

Non-canonical roles of caspase-4 and caspase-5 in heme driven- IL-1β release and cell death

B. E. Bolivar, A. N. Brown, B. A. Rohrman, C. I. Charendoff, V. Yazdani, J. D. Belcher, G. M. Vercellotti, J. M. Flanagan, L. Bouchier-Hayes

This paper identifies extracellular heme as a DAMP that activates caspase-1, caspase-4, and caspase-5, leading to IL-1β release and cell death in macrophages, with caspase-4 playing a primary role in cell death.

bioRxiv · Feb 28, 2020Immunology