Blocking mitochondrial pyruvate import causes energy wasting via futile lipid cycling in brown fat
M. Veliova, C. Mendes Ferreira, I. Y. Benador, A. E. Jones, B. R. Desousa, K. Mahdaviani, R. Acin-Perez, A. Petcherski, A. S. Divakaruni, M. Prentki, B. E. Corkey, M. Liesa, M. F. Oliveira, O. S. Shirihai
The paper shows that blocking mitochondrial pyruvate import increases ATP synthesis via futile lipid cycling in brown adipocytes, enhancing energy expenditure without adrenergic stimulation.
bioRxiv · Nov 15, 2019 · PreprintBiochemistry