O. S. Shirihai

This study develops TFSA nanoparticles that restore lysosomal acidification and improve metabolic function in pancreatic β-cells under lipotoxic conditions.

This study shows that androgen receptor inhibition in prostate cancer cells shifts metabolism to oxidative mitochondrial pathways and increases sensitivity to complex I inhibitors.

The paper shows BT2 acts as a mitochondrial uncoupler, reducing ROS and lipogenesis, which may explain its therapeutic benefits in metabolic diseases.

The paper develops a method to calculate ATP production rates from oxidative phosphorylation and glycolysis using Seahorse XF Analyzer data, enabling direct comparison of ATP sources in live cells.

Mitoquinone mesylate shows antiviral and anti-inflammatory effects against SARS-CoV-2 in preclinical models.

This study uses patient-derived iPSCs with an SFTPC mutation to model early alveolar epithelial dysfunction in interstitial lung disease, revealing proteostasis, metabolic, and inflammatory changes.

This study shows that excessive mitochondrial fission in human CD34+ cells disrupts erythropoiesis and hemoglobin biosynthesis by altering mitochondrial morphology and function.

The paper introduces a machine learning method to segment mitochondria in BAT images, revealing differences in H2O2 production between cytosolic and peri-droplet mitochondria.

The paper shows that blocking mitochondrial pyruvate import increases ATP synthesis via futile lipid cycling in brown adipocytes, enhancing energy expenditure without adrenergic stimulation.

This study shows that nutrient-stimulated histone acetylation regulates the islet epigenome to control adaptive insulin secretion, with Lsd1 playing a key role in this process.

The paper uses live-cell imaging to show mitochondrial cristae undergo continuous fusion and fission, dependent on MIC13, with dynamics similar to crista junctions.

This study identifies NCLX as a critical mitochondrial Na+/Ca2+ exchanger that prevents cell death during adrenergic activation of brown adipose tissue by mitigating Ca2+ overload.