A. E. Jones

Combined effects of matrix stiffness and obesity-associated signaling directs progressive phenotype in PANC-1 pancreatic cancer cells in vitro

This study investigates how matrix stiffness and obesity-associated signaling influence PANC-1 pancreatic cancer cell behavior in vitro, showing increased invasiveness and amoeboid morphology under combined conditions.

Pro-inflammatory macrophage activation does not require inhibition of mitochondrial respiration

This study shows that reduced oxidative phosphorylation is not required for pro-inflammatory macrophage activation, challenging the conventional model of mitochondrial reprogramming.

Simultaneous detection of pathogens and antimicrobial resistance genes with the open source, cloud-based, CZ ID pipeline

The paper develops an open-source, cloud-based tool for detecting pathogens and antimicrobial resistance genes in metagenomic and whole-genome sequencing data, demonstrating its application across clinical and environmental studies.

The metabolic cofactor Coenzyme A enhances alternative macrophage activation via MyD88-linked signaling

This study shows Coenzyme A enhances alternative macrophage activation via MyD88-linked signaling by providing a weak TLR4 signal.

The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis

The paper shows BT2 acts as a mitochondrial uncoupler, reducing ROS and lipogenesis, which may explain its therapeutic benefits in metabolic diseases.

RNA Sensing and Innate Immunity Constitutes a Barrier for Interspecies Chimerism

This study identifies RNA sensing and innate immunity in host embryos as a barrier to interspecies chimerism and shows that modifying host embryos can enhance human cell survival in chimeric embryos.

Proximity-labeling chemoproteomics defines the subcellular cysteinome and inflammation-responsive mitochondrial redoxome

The paper develops Cys-LoC and Cys-LOx methods to map compartment-specific cysteine oxidation states, revealing novel mitochondrial redox modifications in response to inflammation.

Calculation of ATP production rates using the Seahorse XF Analyzer

The paper develops a method to calculate ATP production rates from oxidative phosphorylation and glycolysis using Seahorse XF Analyzer data, enabling direct comparison of ATP sources in live cells.

Blocking mitochondrial pyruvate import causes energy wasting via futile lipid cycling in brown fat

The paper shows that blocking mitochondrial pyruvate import increases ATP synthesis via futile lipid cycling in brown adipocytes, enhancing energy expenditure without adrenergic stimulation.

NCLX prevents cell death during adrenergic activation of the brown adipose tissue

This study identifies NCLX as a critical mitochondrial Na+/Ca2+ exchanger that prevents cell death during adrenergic activation of brown adipose tissue by mitigating Ca2+ overload.