Taxane chemotherapy leads to breast cancer dormancy escape by stromal injury mediated IL-6/MAP2K signaling
R. Ganesan, S. S. Bhasin, U. Krishnan, B. E. Thomas, N. R. Cheemarla, M. K. Bhasin, V. P. Sukhatme
This study shows that taxane chemotherapy induces stromal injury, releasing IL-6 and G-CSF that promote cancer dormancy escape via MEK/ERK signaling, and suggests targeting these cytokines or pathways to prevent recurrence.
bioRxiv · Jul 10, 2022 · PreprintCancer Biology