R. Ganesan

Structural mechanism of angiogenin activation by the ribosome

This study identifies the ribosome as the activator of angiogenin, revealing how it enhances tRNA cleavage efficiency and ensures substrate specificity through structural rearrangements.

Mitochondrial translocation of TFEB regulates complex I and inflammation

This study shows TFEB regulates mitochondrial complex I and inflammation through non-transcriptional mechanisms, with implications for immune pathogenesis during infection.

Taxane chemotherapy leads to breast cancer dormancy escape by stromal injury mediated IL-6/MAP2K signaling

This study shows that taxane chemotherapy induces stromal injury, releasing IL-6 and G-CSF that promote cancer dormancy escape via MEK/ERK signaling, and suggests targeting these cytokines or pathways to prevent recurrence.

Cancer cells adapt FAM134B-BiP complex mediated ER-phagy to survive hypoxic stress

This study shows cancer cells use the FAM134B-BiP complex to trigger ER-phagy under hypoxia, enabling survival, and identifies vitexin as a drug that blocks this process to inhibit breast cancer.

S. Typhimurium impairs glycolysis-mediated acidification of phagosomes to evade macrophage defense

This study shows S. Typhimurium disrupts macrophage glycolysis to prevent phagosome acidification and evade immune defense.

Eocene origin, Miocene diversification and intercontinental dispersal of the genus Drosera (Droseraceae)

This study reconstructs the evolutionary history of Drosera, finding an Eocene origin and Miocene diversification linked to drier climates and dispersal events.

Resolvin D-series regulates Phospholipase D both during inflammation and resolution by modulating phagocyte functions

This study shows that D-series resolvins regulate phospholipase D2 to modulate macrophage polarization and resolution of inflammation.