LRH-1/NR5A2 Activation Rewires Immunometabolism Blunting Inflammatory Immune Cell Progression in Individuals with Type 1 Diabetes and Enhances Human Islet Function in Mice
N. Cobo-vuilleumier, S. Rodriguez-Fernandez, L. Lopez-Noriega, P. I. Lorenzo, J. M. Franco, c. C. Lachaud, E. Martin-Vazquez, R. Araujo Legido, A. Dorronsoro, R. Lopez-Fernandez-Sobrino, b. Fernandez-santos, D. Salas-Lloret, N. van Overbeek, M. Ramos-Rodriguez, C. Mateo-Rodriguez, , B. R. Gauthier
This study shows that activating LRH-1/NR5A2 reduces inflammation in T1D by altering immune cell metabolism and improves human islet function in mice.
bioRxiv · Sep 18, 2023 · PreprintCell Biology