Cell BiologybioRxivPreprint
LRH-1/NR5A2 Activation Rewires Immunometabolism Blunting Inflammatory Immune Cell Progression in Individuals with Type 1 Diabetes and Enhances Human Islet Function in Mice
N. Cobo-vuilleumier, S. Rodriguez-Fernandez, L. Lopez-Noriega…·B. R. Gauthier
This study shows that activating LRH-1/NR5A2 reduces inflammation in T1D by altering immune cell metabolism and improves human islet function in mice.
DOI 10.1101/2023.09.18.558230