Author

P. I. Lorenzo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

B. R. Gauthier· 3 shared F. Martin· 3 shared A. Martin Montalvo· 2 shared c. C. Lachaud· 2 shared E. Martin Vazquez· 2 shared F. J. Bermudez-Silva· 2 shared N. Cobo-vuilleumier· 2 shared R. Araujo Legido· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCell Biology

B. R. Gauthier

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

LRH-1/NR5A2 Activation Rewires Immunometabolism Blunting Inflammatory Immune Cell Progression in Individuals with Type 1 Diabetes and Enhances Human Islet Function in Mice

N. Cobo-vuilleumier, S. Rodriguez-Fernandez, L. Lopez-Noriega, P. I. Lorenzo, J. M. Franco, c. C. Lachaud, E. Martin-Vazquez, R. Araujo Legido, A. Dorronsoro, R. Lopez-Fernandez-Sobrino, b. Fernandez-santos, D. Salas-Lloret, N. van Overbeek, M. Ramos-Rodriguez, C. Mateo-Rodriguez, , B. R. Gauthier

This study shows that activating LRH-1/NR5A2 reduces inflammation in T1D by altering immune cell metabolism and improves human islet function in mice.

bioRxiv · Sep 18, 2023 · PreprintCell Biology

LRH-1/NR5A2 regulates the PTGS2-PGE2-PTGER1 signalling axis contributing to islet survival and antidiabetic actions of the agonist BL001

E. Martin Vazquez, N. Cobo_Vuilleumier, R. Araujo Legido, E. Nola, L. Lopez Bermudo, A. Crespo, S. Y. Romero-Zerbo, M. Garcia-Fernandez, A. Martin Montalvo, A. Rojas, V. Comaills, F. J. Bermudez-Silva, M. Gannon, F. Martin, P. I. Lorenzo, B. R. Gauthier

This study identifies BL001's mechanism of action through LRH-1/NR5A2 activation, showing it protects beta cells via the PTGS2-PGE2-PTGER1 signalling pathway.

bioRxiv · Nov 2, 2021 · PreprintPhysiology

The Metabesity Factor HMG20A Potentiates Astrocyte Survival and Reactivity Preserving Neuronal Integrity

P. I. Lorenzo, E. Fuente-Martin, J. M. Mellado-Gil, J. A. Guerrero Martinez, N. Cobo-Vuilleumier, V. Comaills, E. Martin Vazquez, S. Y. Romero-Zerbo, J. Munoz Franco, J. A. Perez-Caballo, S. Rivero-Canalejo, A. Campo-Caro, C. C. Lachaud, M. Aguilar Diosdado, E. Garcia Fuentes, , B. R. Gauthier

This paper shows HMG20A promotes astrocyte survival and reactivity in the adult brain, preserving neuronal integrity under metabolic stress.

bioRxiv · Feb 15, 2021 · PreprintCell Biology