Author

B. R. Gauthier

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 5 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Organism:human· 2

Frequent Co-Authors

F. J. Bermudez-Silva· 3 shared F. Martin· 3 shared N. Cobo-vuilleumier· 3 shared P. I. Lorenzo· 3 shared S. Y. Romero-Zerbo· 3 shared A. Martin Montalvo· 2 shared c. C. Lachaud· 2 shared E. Martin Vazquez· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersPharmacology & Toxicology

F. J. Bermudez-Silva

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

LRH-1/NR5A2 Activation Rewires Immunometabolism Blunting Inflammatory Immune Cell Progression in Individuals with Type 1 Diabetes and Enhances Human Islet Function in Mice

N. Cobo-vuilleumier, S. Rodriguez-Fernandez, L. Lopez-Noriega, P. I. Lorenzo, J. M. Franco, c. C. Lachaud, E. Martin-Vazquez, R. Araujo Legido, A. Dorronsoro, R. Lopez-Fernandez-Sobrino, b. Fernandez-santos, D. Salas-Lloret, N. van Overbeek, M. Ramos-Rodriguez, C. Mateo-Rodriguez, , B. R. Gauthier

This study shows that activating LRH-1/NR5A2 reduces inflammation in T1D by altering immune cell metabolism and improves human islet function in mice.

bioRxiv · Sep 18, 2023 · PreprintCell Biology

Abnormal Cannabidiol protects pancreatic beta cells in mouse models of experimental Type 1 diabetes

I. Gonzalez-Mariscal, M. Pozo-Morales, S. Y. Romero-Zerbo, V. Espinosa-Jimenez, A. Escamilla-Sanchez, L. Sanchez-Salido, N. Cobo-Vuilleumier, B. R. Gauthier, F. J. Bermudez-Silva

This study shows that Abn-CBD reduces inflammation and protects pancreatic beta cells in mouse models of type 1 diabetes.

Biomedicine & Pharmacotherapy · Jan 1, 2022Peer-reviewedPharmacology & Toxicology

LRH-1/NR5A2 regulates the PTGS2-PGE2-PTGER1 signalling axis contributing to islet survival and antidiabetic actions of the agonist BL001

E. Martin Vazquez, N. Cobo_Vuilleumier, R. Araujo Legido, E. Nola, L. Lopez Bermudo, A. Crespo, S. Y. Romero-Zerbo, M. Garcia-Fernandez, A. Martin Montalvo, A. Rojas, V. Comaills, F. J. Bermudez-Silva, M. Gannon, F. Martin, P. I. Lorenzo, B. R. Gauthier

This study identifies BL001's mechanism of action through LRH-1/NR5A2 activation, showing it protects beta cells via the PTGS2-PGE2-PTGER1 signalling pathway.

bioRxiv · Nov 2, 2021 · PreprintPhysiology

The Metabesity Factor HMG20A Potentiates Astrocyte Survival and Reactivity Preserving Neuronal Integrity

P. I. Lorenzo, E. Fuente-Martin, J. M. Mellado-Gil, J. A. Guerrero Martinez, N. Cobo-Vuilleumier, V. Comaills, E. Martin Vazquez, S. Y. Romero-Zerbo, J. Munoz Franco, J. A. Perez-Caballo, S. Rivero-Canalejo, A. Campo-Caro, C. C. Lachaud, M. Aguilar Diosdado, E. Garcia Fuentes, , B. R. Gauthier

This paper shows HMG20A promotes astrocyte survival and reactivity in the adult brain, preserving neuronal integrity under metabolic stress.

bioRxiv · Feb 15, 2021 · PreprintCell Biology

Roles for the long non-coding RNA Pax6os1/PAX6-AS1 in pancreatic beta cell identity and function.

L. Lopez-Noriega, R. M. Callingham, A. Martinez-sanchez, S. Nawaz, G. Pizza, N. Haberman, N. Cvetesic, M.-S. Nguyen-Tu, B. Lenhard, P. Marchetti, L. Piemonti, E. J. P. de Koning, A. M. J. Shapiro, P. R. Johnson, I. Leclerc, , G. A. Rutter

This study investigates the role of Pax6os1/PAX6-AS1 in beta cell identity and function, finding that its upregulation in diabetes contributes to impaired functionality and that targeting it may improve glucose homeostasis.

bioRxiv · Jul 17, 2020 · PreprintCell Biology