Author

L. Lopez-Noriega

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Physiology· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 5 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:microscopy & imaging analysis· 2

Frequent Co-Authors

G. A. Rutter· 5 shared I. Leclerc· 5 shared E. Akalestou· 3 shared A. Martinez-sanchez· 2 shared B. R. Gauthier· 2 shared L. Piemonti· 2 shared A. C. Vertegaal· 1 shared A. Campos Caro· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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5 shared papersCell Biology

G. A. Rutter

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Author profile →

6 papers

Recent·Most cited

LRH-1/NR5A2 Activation Rewires Immunometabolism Blunting Inflammatory Immune Cell Progression in Individuals with Type 1 Diabetes and Enhances Human Islet Function in Mice

N. Cobo-vuilleumier, S. Rodriguez-Fernandez, L. Lopez-Noriega, P. I. Lorenzo, J. M. Franco, c. C. Lachaud, E. Martin-Vazquez, R. Araujo Legido, A. Dorronsoro, R. Lopez-Fernandez-Sobrino, b. Fernandez-santos, D. Salas-Lloret, N. van Overbeek, M. Ramos-Rodriguez, C. Mateo-Rodriguez, , B. R. Gauthier

This study shows that activating LRH-1/NR5A2 reduces inflammation in T1D by altering immune cell metabolism and improves human islet function in mice.

bioRxiv · Sep 18, 2023 · PreprintCell Biology

Molecular phenotyping of single pancreatic islet leader beta cells by Flash-Seq

P. Chasbosseau, F. Yong, L. Delgadillo-Silva, E. Young Lee, S. Li, N. Gandhi, J. Wastin, L. Lopez-Noriega, I. Leclerc, Y. Ali, J. HUGHES, R. Sladek, A. Martinez-sanchez, G. A. Rutter

The paper identifies leader beta cells in pancreatic islets using Flash-Seq and finds they have a distinct transcriptome and localization compared to follower cells.

bioRxiv · Aug 26, 2022Cell Biology

Bariatric surgery normalizes circulating glucocorticoid levels and lowers glucocorticoid action tissue-selectively in mice

E. Akalestou, L. Lopez-Noriega, I. Christakis, A. Miras, I. Leclerc, G. A. Rutter

This study shows bariatric surgery lowers glucocorticoid levels and reduces tissue-specific glucocorticoid activity in mice, improving insulin sensitivity without significant weight loss.

bioRxiv · Jul 23, 2020 · PreprintPhysiology

Roles for the long non-coding RNA Pax6os1/PAX6-AS1 in pancreatic beta cell identity and function.

L. Lopez-Noriega, R. M. Callingham, A. Martinez-sanchez, S. Nawaz, G. Pizza, N. Haberman, N. Cvetesic, M.-S. Nguyen-Tu, B. Lenhard, P. Marchetti, L. Piemonti, E. J. P. de Koning, A. M. J. Shapiro, P. R. Johnson, I. Leclerc, , G. A. Rutter

This study investigates the role of Pax6os1/PAX6-AS1 in beta cell identity and function, finding that its upregulation in diabetes contributes to impaired functionality and that targeting it may improve glucose homeostasis.

bioRxiv · Jul 17, 2020 · PreprintCell Biology

Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice

E. Akalestou, K. Suba, L. Lopez-Noriega, E. Georgiadou, P. Chabosseau, I. Leclerc, V. Salem, G. A. Rutter

This study uses intravital imaging to show that bariatric surgery enhances β cell connectivity and Ca2+ dynamics in mice, leading to improved glucose tolerance and insulin secretion.

bioRxiv · May 5, 2020Cell Biology

Vertical sleeve gastrectomy lowers kidney SGLT2 expression in the mouse

E. Akalestou, L. Lopez-Noriega, I. Leclerc, G. A. Rutter

This study shows that vertical sleeve gastrectomy reduces kidney SGLT2 expression in mice, which may explain improved glucose tolerance after bariatric surgery.

bioRxiv · Aug 21, 2019 · PreprintPhysiology