Insulin resistance-driven beta-cell adaptation in mice: Mechanistic characterization and 3D analysis
A. Liboz, C. Beaupere, N. Roblot, J.-Y. Tinevez, S. Guilmeau, A.-F. Burnol, D. Gueddouri, X. Prieur, B. Feve, G. Guillemain, B. Blondeau
This study characterizes beta-cell adaptation to insulin resistance in mice, showing that neogenesis is a key mechanism, persists with aging, and is confirmed by a new 3D analysis method.
bioRxiv · Jan 9, 2023 · PreprintPhysiology