Author

B. Freie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

R. N. Eisenman· 3 shared E. Babaeva· 2 shared H. Mathsyaraja· 2 shared P.-F. Cheng· 2 shared A. Koehne· 1 shared A. M. Houghton· 1 shared B. J. Varnum-Finney· 1 shared D. Janssens· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCancer Biology

R. N. Eisenman

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3 papers

Recent·Most cited

A Germline Point Mutation in the MYC-FBW7 Phosphodegron Initiates Hematopoietic Malignancies

B. Freie, P. A. Carroll, B. J. Varnum-Finney, V. Ramani, I. Bernstein, R. N. Eisenman

This study shows a single point mutation in Myc leads to hematopoietic malignancies by altering MYC function in progenitor cells.

bioRxiv · Oct 23, 2023Cancer Biology

Loss of MGA mediated Polycomb repression promotes tumor progression and invasiveness

H. Mathsyaraja, J. Catchpole, E. Eastwood, E. Babaeva, M. J. Geuenich, P.-F. Cheng, B. Freie, J. L. Ayers, M. Yu, N. Wu, K. R. Poudel, A. Koehne, W. Grady, A. M. Houghton, Y. Shiio, , R. N. Eisenman

This study shows that loss of MGA promotes tumor growth and invasiveness by de-repressing Polycomb targets in lung and colon cancers.

eLife · Jul 8, 2021Peer-reviewedCancer Biology

Max deletion destabilizes MYC protein and abrogates Eμ-Myc lymphomagenesis

H. Mathsyaraja, B. Freie, P.-F. Cheng, E. Babaeva, D. Janssens, S. Henikoff, R. N. Eisenman

The paper shows that deleting Max reduces MYC protein levels and prevents Eμ-Myc lymphomagenesis, but has minimal effect on B-cell development.

bioRxiv · Feb 21, 2019Cancer Biology