Deep mutational scanning highlights a new role for cytosolic regions in Hrd1 function
B. G. Peterson, J. Hwang, J. E. Russ, J. Schroeder, P. L. Freddolino, R. D. Baldridge
The paper identifies cytosolic regions in Hrd1 critical for lumenal ERAD substrate degradation through deep mutational scanning and functional assays.
bioRxiv · Apr 3, 2023Biochemistry