Author

P. L. Freddolino

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1 Ecology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:chromatin & epigenetic regulation· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Organism:bacteria (other)· 2 Research Focus:cell signaling & trafficking· 2 Assay:DNA methylation· 2 Organism:E. coli· 2

Frequent Co-Authors

A. J. Finch· 1 shared A. Tailleux· 1 shared B. B. Barros· 1 shared B. Emerson· 1 shared B. G. Peterson· 1 shared B. Staels· 1 shared C. A. Ziegler· 1 shared C. Haynes· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperPhysiology

A. J. Finch

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6 papers

Recent·Most cited

Deep mutational scanning highlights a new role for cytosolic regions in Hrd1 function

B. G. Peterson, J. Hwang, J. E. Russ, J. Schroeder, P. L. Freddolino, R. D. Baldridge

The paper identifies cytosolic regions in Hrd1 critical for lumenal ERAD substrate degradation through deep mutational scanning and functional assays.

bioRxiv · Apr 3, 2023Biochemistry

A legacy role for DNA binding of Lon protects against genotoxic stress

R. D. Zeinert, J. Ogdahl, J. Liu, Q. Yang, Y. Du, B. B. Barros, P. L. Freddolino, C. Haynes, P. Chien

The paper shows that Lon protease DNA binding protects bacteria and mitochondria from genotoxic stress by clearing bound proteins.

bioRxiv · Dec 27, 2022 · PreprintMicrobiology

E. coli Leucine-responsive regulatory protein bridges DNA in vivo and tunably dissociates in the presence of exogenous leucine

C. A. Ziegler, P. L. Freddolino

This study investigates how E. coli Lrp oligomerization state and exogenous leucine affect DNA binding and gene regulation.

bioRxiv · Mar 7, 2022 · PreprintMicrobiology

Escherichia coli YigI is a conserved γ-proteobacterial acyl-CoA thioesterase permitting metabolism of unusual fatty acid substrates

M. Schmidt, T. Proctor, R. Diao, P. L. Freddolino

This study identifies YigI as a third acyl-CoA thioesterase in E. coli involved in CLA degradation, showing distinct regulatory conditions compared to other thioesterases.

bioRxiv · Jan 10, 2022 · PreprintMicrobiology

Gut Fungi Possess a Conserved Toxin Immunity Gene of Bacterial Origin

S. M. Rizvi, C. Zhang, P. L. Freddolino, Y. Zhang

The paper identifies a bacterial toxin immunity gene acquired by gut fungi through horizontal gene transfer, providing evidence of its role in fungal survival in the gut microbiome.

bioRxiv · Oct 15, 2020 · PreprintEcology

The hepatic compensatory response to elevated systemic sulfide promotes diabetes

R. N. Carter, M. T. G. Gibbins, M. E. Barrios-Llerena, S. E. Wilkie, P. L. Freddolino, M. Libiad, V. Vitvitsky, B. Emerson, T. Le Bihan, M. Brice, H. Su, S. G. Denham, N. Z. M. Homer, C. Mc Fadden, A. Tailleux, , N. M. Morton

This study shows that mice lacking the sulfide oxidation pathway enzyme TST exhibit metabolic abnormalities despite insulin sensitization, highlighting TST's role in hepatic metabolism and potential implications for sulfide-donor therapies.

bioRxiv · Apr 27, 2020Physiology