Author

B. Gan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:cryo-EM· 2 Research Focus:protein structure prediction· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

C. Wang· 2 shared H. Hu· 2 shared L. Yu· 2 shared R. Ren· 2 shared B. Pang· 1 shared C. Bolch· 1 shared D. Rafferty· 1 shared H. Jiao· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersCancer Biology

C. Wang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

DePARylation is critical for S phase progression and cell survival

L. Nie, C. Wang, M. Huang, X. Liu, X. Feng, M. Tang, S. Li, Q. Hang, H. Teng, X. Shen, L. Ma, B. Gan, J. Chen

This study shows that dePARylation by PARG is essential for S phase progression and cell survival, with PARG inhibition causing cytotoxicity through pADPr accumulation.

bioRxiv · Jul 31, 2023Cancer Biology

The structural basis of itch receptor MRGPRX1 activation

B. Gan, L. Yu, H. Yang, H. Jiao, B. Pang, Y. Chen, C. Wang, R. Lv, H. Hu, Z. Cao, R. Ren

This study reports the cryo-EM structure of MRGPRX1 bound to an agonist, revealing its activation mechanism and guiding the design of specific modulators for itch and pain treatment.

bioRxiv · Dec 21, 2022 · PreprintBiochemistry

Elimination of Foxo triplets following glucocorticoid incubation dampened metabolic stress and enhanced anti-viral response targets based on transcriptomic analysis

P. Puthanveetil, D. Rafferty, B. Gan, C. Bolch

The paper shows that deleting Foxo triplets in mouse cells reduces metabolic stress and enhances anti-viral response while maintaining anti-inflammatory effects of glucocorticoids.

bioRxiv · Nov 17, 2022 · PreprintPharmacology & Toxicology

Structural Insights into Sphingosine-1-phosphate Receptor Activation

L. Yu, L. He, B. Gan, R. Ti, Q. Xiao, H. Hu, L. Zhu, S. Wang, R. Ren

This study reports cryo-EM structures of S1PR1 bound to different agonists, revealing activation mechanisms and a two-step transition process for CBP-307.

bioRxiv · Jan 15, 2022Biochemistry