DePARylation is critical for S phase progression and cell survival
L. Nie, C. Wang, M. Huang, X. Liu, X. Feng, M. Tang, S. Li, Q. Hang, H. Teng, X. Shen, L. Ma, B. Gan, J. Chen
This study shows that dePARylation by PARG is essential for S phase progression and cell survival, with PARG inhibition causing cytotoxicity through pADPr accumulation.
bioRxiv · Jul 31, 2023Cancer Biology