B. Jenkins

Pathological levels of α-synuclein increase basal mitophagy in Parkinson's dopamine neurons

This study shows that elevated α-synuclein increases basal mitophagy in Parkinson's dopamine neurons, leading to mitochondrial dysfunction and neuronal activity deficits, which can be reversed by DRP1 inhibition.

Ablation of Sam50 is associated with fragmentation and alterations in metabolism in murine and human myotubes

This study shows that Sam50 deficiency in myotubes leads to mitochondrial fragmentation, altered metabolism, and impaired oxidative capacity in both mice and humans.

Quantitative analysis of food web dynamics in a low export ecosystem

The paper quantifies food web dynamics in a low export ecosystem, finding microbial recycling dominates carbon flow with minimal export due to slow turnover and high detrital background.

A single full-length VAR2CSA ectodomain variant purifies broadly neutralizing antibodies against placental malaria isolates

The paper purifies broadly neutralizing antibodies against placental malaria isolates using a single VAR2CSA ectodomain variant and shows it targets epitopes shared by multiple parasites.

Placental polyamines regulate acetyl-coA and histone acetylation in a sex-dependent manner

The paper shows that placental polyamines affect acetyl-CoA and histone acetylation differently in males and females, linking these changes to pregnancy complications.

A high affinity human monoclonal antibody against Pfs230 binds multiple parasite stages and blocks oocyst formation in mosquitoes

The paper identifies a high-affinity human monoclonal antibody against Pfs230 that blocks oocyst formation in mosquitoes by targeting gamete surfaces.

Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity

This study shows that increased phosphatidylcholine synthesis in macrophages during obesity drives inflammation in adipose tissue, contributing to insulin resistance.

Microtubule acetylation is required for mechanosensation in Drosophila

This study shows that microtubule acetylation via dTAT is essential for mechanosensation in Drosophila, affecting touch, gravity, and sound responses but not thermal sensing.

Effects of mutating α-tubulin lysine 40 on sensory dendrite development

This study shows that mutating α-tubulin lysine 40 affects dendrite branch refinement in sensory neurons but not survival, suggesting a role for acetylation in dendritic morphogenesis.