Structural insights into loss of function of a pore forming toxin and its role in pneumococcal adaptation to an intracellular lifestyle
D. C. Badgujar, A. Anil, A. E. Green, M. V. Surve, S. Madhavan, A. Beckett, I. Prior, B. K. Godsora, S. B. Patil, P. K. More, S. Guha Sarkar, A. Mitchell, R. Banerjee, P. P. Phale, T. J. Mitchell, , A. Banerjee
This paper identifies structural changes in a non-hemolytic pneumolysin variant that disable pore formation, enabling pneumococcus to adopt an intracellular lifestyle with reduced inflammation and increased host tolerance.
PLOS Pathogens · Nov 20, 2020Peer-reviewedMicrobiology