Author

B. L. O'Donnell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

S. Penuela· 4 shared D. Johnston· 3 shared S. Sayedyahossein· 3 shared C. B. Wakefield· 2 shared F. Beier· 2 shared J. Tang· 2 shared L. Dagnino· 2 shared R. E. Sanchez-Pupo· 2 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersPhysiology

S. Penuela

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Pannexin 1 and Pannexin 3 differentially regulate the tumorigenic properties of cutaneous squamous cell carcinoma

B. L. O'Donnell, D. Johnston, A. Bhatt, Z. Kardan, D. Stefan, A. Bysice, S. Sayedyahossein, L. Dagnino, M. Cecchini, S. K. Loganathan, K. Roth, S. Penuela

This study investigates the differential roles of PANX1 and PANX3 in cutaneous squamous cell carcinoma, finding PANX1 promotes tumorigenesis while PANX3 suppresses it.

bioRxiv · Apr 8, 2024 · PreprintCancer Biology

Severe Osteoarthritis in Aged PANX3 Knockout Mice: Implications for a Novel Primary Osteoarthritis Model

B. Wakefield, J. Tang, J. Balanta Melo, J. L. Hutchinson, R. Kanji, G. Herold, B. L. O'Donnell, C. Brooks, P. Kiser, M. Grol, C. A. Seguin, L. I. Plotkin, F. Beier, S. Penuela

This study shows that aged PANX3 knockout mice develop severe primary osteoarthritis, suggesting PANX3 deletion harms joint health in aging.

bioRxiv · Jul 4, 2023Physiology

Pannexin 3 channels regulate architecture, adhesion, barrier function and inflammation in the skin

B. L. O'Donnell, R. E. Sanchez-Pupo, S. Sayedyahossein, M. Karimi, M. Bahmani, C. Zhang, D. Johnston, J. Kelly, C. B. Wakefield, K. Barr, L. Dagnino, S. Penuela

This study shows PANX3 is essential for maintaining skin architecture, adhesion, barrier function, and inflammation during aging, as demonstrated in knockout mice.

bioRxiv · Jul 13, 2022Cell Biology

Pannexin 3 deletion reduces fat accumulation and inflammation in a sex-specific manner

C. B. Wakefield, V. R. Lee, D. Johnston, P. Boroumand, N. J. Pillon, S. Sayedyahossein, B. L. O'Donnell, J. Tang, R. E. Sanchez-Pupo, K. J. Barr, R. Gros, L. E. Flynn, N. Borradaile, A. Klip, F. Beier, S. Penuela

This study shows that PANX3 deletion reduces fat mass and inflammation in male mice but not females, with male KOs having fewer adipocytes and lower inflammatory gene expression.

bioRxiv · May 4, 2021Physiology