M. Karimi

Pannexin 3 channels regulate architecture, adhesion, barrier function and inflammation in the skin

This study shows PANX3 is essential for maintaining skin architecture, adhesion, barrier function, and inflammation during aging, as demonstrated in knockout mice.

Mucosal and systemic responses to SARS-CoV-2 vaccination in infection naive and experienced individuals

This study examines immune responses to SARS-CoV-2 vaccination in individuals with and without prior infection, finding higher antibody levels and neutralizing titers in previously infected individuals.

Wnt/β-catenin regulates alloreactive T cells for the treatment of hematological malignancies

This study shows that β-catenin regulates donor T cells in allo-HSCT, reducing GVHD while preserving GVL effects through altered cytokine production and cytotoxicity.

TCF-1 in CD4 T cells regulates GVHD severity and persistence

This study shows that loss of TCF-1 in mature CD4 T cells reduces GVHD severity and persistence by impairing T cell function and increasing exhaustion.

TCF-7 is dispensable for the anti-tumor response but required for the persistent function of mature CD8 T cells

This study shows TCF-7 is not needed for anti-tumor response but is required for long-term function of mature CD8 T cells.

Loss of TCF-1 regulates the production of noncanonical Tregs in a prion-like manner

The paper shows that loss of TCF-1 expands noncanonical Tregs and that TCF-1-deficient T cells promote their production from wild-type cells.

Amino acids targeted based metabolomics study in non-segmental Vitiligo: a pilot study

This study uses metabolomics to analyze amino acid profiles in vitiligo patients, identifying biomarkers associated with disease severity and potential pathogenic mechanisms.

Inhibition of ITK differentiates GVT and GVHD in allo-HSCT

This paper shows that inhibiting ITK in donor T cells reduces GVHD while preserving GVT effects in allo-HSCT using murine models and a novel peptide inhibitor.

Altered N-glycan composition impacts flagella mediated adhesion in Chlamydomonas reinhardtii

This study shows that altered N-glycan composition in Chlamydomonas reinhardtii reduces flagella-mediated adhesion and surface binding.

CrkL is required for donor T cell migration to GvHD Target organs

This study identifies CrkL as essential for donor T cell migration to GvHD target organs, showing that CrkL-deficient T cells cannot migrate into inflamed tissues but can still eliminate hematopoietic tumors.

CRISPR-TSKO facilitates efficient cell type-, tissue-, or organ-specific mutagenesis in Arabidopsis

CRISPR-TSKO enables efficient, specific mutagenesis in Arabidopsis cell types, tissues, or organs, avoiding pleiotropic effects by generating somatic mutations.

The SERM/SERD Bazedoxifene Disrupts ESR1 Helix 12 to Overcome Acquired Hormone Resistance in Breast Cancer Cells

This study shows that bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells by inhibiting Y537S and D538G ER mutants more effectively than tamoxifen.