Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations
U. Rovsnik, Y. Zhuang, B. O. Forsberg, M. Carroni, L. Yvonnesdotter, R. J. Howard, E. Lindahl
The paper reports cryo-EM structures and simulations of GLIC under different pH conditions, revealing conformational changes and electrostatic remodeling during proton-induced gating.
bioRxiv · Jan 4, 2021Biochemistry