Author

B. Obeng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:microscopy & imaging analysis· 2 Approach:biophysical modeling· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

J. A. Gosse· 4 shared B. E. West· 3 shared J. E. Burnell· 3 shared J. K. Shim· 3 shared C. M. Potts· 2 shared E. L. Ledue· 2 shared M. S. Kinney· 2 shared P. J. Fleming· 2 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersPharmacology & Toxicology

J. A. Gosse

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4 papers

Recent·Most cited

Antimicrobial cetylpyridinium chloride suppresses mast cell function by targeting tyrosine phosphorylation of Syk kinase

B. Obeng, L. J. Bennett, B. E. West, D. J. Wagner, P. J. Fleming, M. N. Tasker, M. K. Lorenger, D. R. Smith, T. Systuk, S. M. Plummer, J. Eom, M. D. Paine, C. T. Frangos, M. P. Wilczek, J. K. Shim, , J. A. Gosse

This study shows that cetylpyridinium chloride inhibits mast cell function by disrupting tyrosine phosphorylation of Syk kinase and LAT, without affecting Lyn kinase.

bioRxiv · Jul 4, 2024 · PreprintPharmacology & Toxicology

Pharmaceutical agent cetylpyridinium chloride inhibits immune mast cell function by interfering with calcium mobilization

B. Obeng, C. M. Potts, B. E. West, J. E. Burnell, P. J. Fleming, J. K. Shim, M. S. Kinney, E. L. Ledue, S. Sangroula, A. Y. B. Vazquez, J. A. Gosse

This study shows that cetylpyridinium chloride inhibits mast cell degranulation by disrupting calcium mobilization without affecting plasma membrane potential or pH.

Food and Chemical Toxicology · Sep 1, 2023Peer-reviewedPharmacology & Toxicology

Mechanisms of Antimicrobial Agent Cetylpyridinium Chloride Mitochondrial Toxicity in Rodent and Primary Human Cells: Super-resolution Microscopy Reveals Nanostructural Disruption

S. R. Weller, J. E. Burnell, B. M. Aho, B. Obeng, E. L. Ledue, J. K. Shim, S. T. Hess, J. A. Gosse

This study shows that cetylpyridinium chloride (CPC) inhibits mitochondrial ATP production and causes nanostructural mitochondrial defects in rodent and human cells.

bioRxiv · Sep 27, 2022 · PreprintPharmacology & Toxicology

Cetylpyridinium chloride (CPC) reduces zebrafish mortality from influenza infection: Super-resolution microscopy reveals CPC interference with multiple protein interactions with phosphatidylinositol 4,5-bisphosphate in immune function

P. Raut, S. R. Weller, B. Obeng, B. L. Soos, B. E. West, C. M. Potts, S. Sangroula, M. S. Kinney, J. E. Burnell, B. L. King, J. A. Gosse, S. T. Hess

This paper shows that cetylpyridinium chloride (CPC) reduces zebrafish mortality and viral load from influenza by interfering with phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent protein interactions.

bioRxiv · Oct 8, 2021Biophysics