B. Williams

Antagonistic effects of actin-specific toxins on Salmonella Typhimurium invasion into mammalian cells

The paper shows that actin-specific toxins from different bacteria inhibit each other's ability to disrupt the host actin cytoskeleton, revealing a mechanism of bacterial competition.

Accurate evaluation of live-virus microneutralisation for SARS-CoV-2 variant JN.1

The paper evaluates neutralising antibody titres against SARS-CoV-2 variant JN.1 using live-virus microneutralisation assays in vaccinated individuals, finding higher titres in monovalent vaccine recipients.

Terrestrial 3D Laser Scanning for Ecosystem and Fire Effects Monitoring

This paper introduces terrestrial laser scanning as an efficient, affordable method for ecosystem monitoring, enhancing data quality and repeatability through standardized data collection and automated analysis.

In-Space Fabrication of Janus Base Nano-Matrix for Improved Assembly and Bioactivities

The paper demonstrates the fabrication of DNA-inspired Janus base nanomaterials in space, showing their potential for in-space manufacturing.

Unlocking the soundscape of coral reefs with artificial intelligence: pretrained networks and unsupervised learning win out

This paper demonstrates that pretrained neural networks and unsupervised learning effectively analyze coral reef soundscapes for ecological insights without manual annotation.

Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer

The paper shows that ZNRF3/RNF43 ubiquitinates and degrades EGFR, and their loss increases EGFR signaling, promoting cancer growth.

Optimal investments in private land conservation depend more on landholder preferences than climate change

This study shows that landholder preferences are more important than climate change for optimizing private land conservation investments in koala habitats in New South Wales.

Dichotomy of neutralizing antibody, B cell and T cell responses to SARS-CoV-2 vaccination and protection in healthy adults

The paper identifies four patterns of SARS-CoV-2 vaccine responses, including broad and narrow responders, and links broad responder traits to longer infection-free time after vaccination.

D614G and Omicron SARS-CoV-2 variant spike proteins differ in the effects of N-glycan modifications on spike expression, virus infectivity, and neutralization by some therapeutic antibodies

This study compares how N-glycan modifications affect spike expression, infectivity, and antibody neutralization in SARS-CoV-2 D614G and Omicron variants.

Emergence of new subgenomic mRNAs in SARS-CoV-2

This study identifies new subgenomic mRNAs in SARS-CoV-2 arising from mutations that create novel transcription regulatory sequences, leading to the expression of functional proteins like N.iORF3.

The ENDS of assumptions; an online tool for the Epistemic Nonparametric Drug-response Scoring

The paper introduces nonparametric models for drug dose-response curve fitting and provides an online tool for analysis.

Qualification of ELISA and neutralization methodologies to measure SARS-CoV-2 humoral immunity using human clinical samples

This paper qualifies ELISA and neutralization assays to measure SARS-CoV-2 humoral immunity using clinical samples, evaluating antibody titers and functional neutralization capacity.

Desiccation-driven senescence and its repression in Xerophyta schlechteri are regulated at extremely low water contents

This study identifies molecular mechanisms of desiccation-driven senescence in Xerophyta schlechteri and proposes a regulatory model based on homology with Arabidopsis senescence regulators.

Integrating deep learning and unbiased automated high-content screening to identify complex disease signatures in human fibroblasts

This study develops a platform combining deep learning and high-content imaging to identify disease-specific phenotypes in Parkinson's fibroblasts, achieving high accuracy in distinguishing disease subtypes.

Liver x receptor alpha drives chemoresistance in response to side-chain hydroxycholesterols in triple negative breast cancer

This study identifies LXRalpha as a driver of chemoresistance in TNBC through its regulation of P-glycoprotein, linking cholesterol metabolism to chemotherapy failure.

Laser-activated drug implant for controlled release to the posterior segment of the eye

This paper develops a laser-activated drug implant for controlled release in the posterior eye, showing in vitro and in vivo drug release kinetics and safety.

Only ten percent of the global terrestrial protected area network is connected via intact land

The paper assesses global protected area connectivity and finds only 9.7% of terrestrial protected areas are connected via intact land.

Protein polyglutamylation catalyzed by the bacterial Calmodulin-dependent pseudokinase SidJ

This study identifies SidJ as a bacterial pseudokinase that catalyzes polyglutamylation of SdeA, a Legionella effector, in a CaM-dependent manner, suppressing ADP-ribosylation.