Loss of TP53 mediates suppression of Macrophage Effector Function via Extracellular Vesicles and PDL1 towards Resistance against Chemoimmunotherapy in B-cell malignancies
E. Izquierdo, D. Vorholt, B. Sackey, J. Nolte, S. J. Blakemore, J. Schmitz, V. Barbarino, N. Nickel, D. Bachurski, L. Lobastova, M. Nikolic, M. Michalik, R. Brinker, R. Neuhaus, L. Frenzel, , C. Pallasch
This paper identifies that TP53 loss in B-cell lymphoma leads to resistance against chemoimmunotherapy by suppressing macrophage effector function through PDL1-expressing extracellular vesicles.
bioRxiv · Jun 11, 2020 · PreprintCell Biology