Author

R. Neuhaus

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1

Frequent Co-Authors

C. Pallasch· 2 shared D. Vorholt· 2 shared M. Krueger· 2 shared A. Bansal· 1 shared A. Gradillas· 1 shared A. Hilpmann· 1 shared A. J. Garcia-Civico· 1 shared A. Kramm· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCell Biology

C. Pallasch

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Allergic inflammation triggers dyslipidemia via IgG signalling

N. Fernandez-Gallego, R. Castillo-Gonzalez, L. Moreno-Serna, A. J. Garcia-Civico, E. Sanchez-Martinez, C. Lopez-Sanz, A. L. Fontes, L. L. Pimentel, A. Gradillas, D. Obeso, R. Neuhaus, M. Ramirez-Huesca, I. Ruiz-Fernandez, E. Nunez-Borque, Y. R. Carrasco, , R. Jimenez-Saiz

This study shows that IgG-mediated allergic inflammation increases serum triglycerides and alters lipid metabolism in mice and humans.

bioRxiv · Aug 4, 2023Immunology

Loss of TP53 mediates suppression of Macrophage Effector Function via Extracellular Vesicles and PDL1 towards Resistance against Chemoimmunotherapy in B-cell malignancies

E. Izquierdo, D. Vorholt, B. Sackey, J. Nolte, S. J. Blakemore, J. Schmitz, V. Barbarino, N. Nickel, D. Bachurski, L. Lobastova, M. Nikolic, M. Michalik, R. Brinker, R. Neuhaus, L. Frenzel, , C. Pallasch

This paper identifies that TP53 loss in B-cell lymphoma leads to resistance against chemoimmunotherapy by suppressing macrophage effector function through PDL1-expressing extracellular vesicles.

bioRxiv · Jun 11, 2020 · PreprintCell Biology

ATM-mediated DNA damage response in macrophages primes phagocytosis and immune checkpoint regulation

A. Bansal, R. Neuhaus, E. Izquierdo-Alvarez, H. Nolte, D. Vorholt, H. Feldkoetter, P. Lohneis, R. Buettner, M. Krueger, C. Pallasch, B. Schumacher

The paper shows that DNA damage in macrophages increases PD-L1 expression and phagocytic activity, suggesting a role in chemotherapy response and immune checkpoint regulation.

bioRxiv · Mar 14, 2020 · PreprintImmunology

Targeting a Therapy-Resistant Cancer Cell State Using Masked Electrophiles as GPX4 Inhibitors

J. K. Eaton, L. Furst, R. A. Ruberto, D. Moosmayer, R. C. Hillig, A. Hilpmann, K. Zimmermann, M. J. Ryan, M. Niehues, V. Badock, A. Kramm, S. Chen, P. A. Clemons, S. Gradl, C. Montagnon, , S. L. Schreiber

This paper identifies nitrile oxide electrophiles as a new class of GPX4 inhibitors that overcome limitations of existing chloroacetamide-based inhibitors.

bioRxiv · Sep 5, 2018Biochemistry