Author

B. Siebers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

C. Braesen· 2 shared F. Kaschani· 2 shared M. Kaiser· 2 shared S. Ninck· 2 shared A. J. Probst· 1 shared A. Schramm· 1 shared B. Tjaden· 1 shared B. Wassmer· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersMicrobiology

C. Braesen

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Glycerol degradation in the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius involves an unusual glycerol-3-phosphate dehydrogenase

C. Schmerling, C. Schroeder, X. Zhou, T. Busche, J. Kalinowski, L. Montero, O. Schmitz, F. Kaschani, S. Ninck, M. Kaiser, J. Bost, B. Wassmer, S.-V. Albers, B. Siebers, C. Braesen

This study identifies an unusual glycerol-3-phosphate dehydrogenase in Sulfolobus acidocaldarius involved in glycerol degradation, showing its essential role in growth on glycerol.

bioRxiv · Feb 29, 2024 · PreprintMicrobiology

Protein kinase Sut1 from the Crenarchaeon Sulfolobus acidocaldarius displays tyrosine phosphorylation activity

H. R. Maklad, S. P. d. Ruys, I. Bervoets, D. Vertommen, G. J. Gutierrez, W. F. Vranken, B. Siebers, E. Peeters

The paper identifies and characterizes Sut1, a tyrosine kinase in Sulfolobus acidocaldarius, showing it phosphorylates tyrosine residues in vitro and belongs to a novel archaeal kinase family.

bioRxiv · Jan 14, 2024 · PreprintMicrobiology

Environmental activity-based protein profiling for function-driven enzyme discovery from natural communities

S. Ninck, T. Klaus, T. V. Kochetkova, S. P. Esser, L. Sewald, F. Kaschani, C. Braesen, A. J. Probst, I. Kublanov, B. Siebers, M. Kaiser

This paper introduces eABPP, a proteomics-based method to identify active enzymes in microbial communities, and demonstrates its application in discovering thermostable serine hydrolases from hot springs.

bioRxiv · Nov 11, 2022 · PreprintBiochemistry

MYCN-induced metabolic rewiring creates novel therapeutic vulnerabilities in neuroblastoma

B. Tjaden, K. Baum, V. Marquardt, M. Simon, M. Trajkovic-Arsic, T. Kouril, B. Siebers, J. Lisec, J. T. Siveke, J. H. Schulte, U. Benary, M. Remke, J. Wolf, A. Schramm

This study shows that MYCN overexpression in neuroblastoma cells rewires metabolism, creating vulnerabilities that can be targeted with metabolic inhibitors.

bioRxiv · Sep 25, 2018Cancer Biology