Phage resistance accompanies reduced fitness of uropathogenic E. coli in the urinary environment
J. J. Zulk, J. R. Clark, S. Ottinger, M. B. Ballard, M. E. Mejia, V. Mercado, E. R. Heckmann, B. C. Sanchez, B. W. Trautner, A. W. Maresso, K. A. Patras
This study shows that phage resistance in UPEC arises quickly in the urinary environment but comes with fitness costs that reduce bacterial growth and virulence.
bioRxiv · Dec 2, 2021 · PreprintMicrobiology