A. Rajan

Playback-aided surveys and acoustic monitoring in the detection of the Endangered Forest Owlet Athene blewitti

The paper evaluates playback-aided surveys and acoustic monitoring to detect the Forest Owlet in the Dang region, finding increased detections with new techniques but uncertainty about population trends.

BPP43_05035 is a Brachyspira pilosicoli cell surface adhesin that weakens the integrity of the epithelial barrier during infection

This study identifies BPP43_05035 as a Brachyspira pilosicoli adhesin that disrupts epithelial tight junctions, increasing barrier permeability during infection.

Pediatric human nose organoids demonstrate greater susceptibility, epithelial responses, and cytotoxicity than adults during RSV infection.

This study compares RSV infection responses in pediatric and adult nose organoids, finding pediatric organoids show greater susceptibility, cytokine response, and cellular damage.

Functional Genomics of Gastrointestinal Escherichia coli Isolated from Patients with Cancer and Diarrhea

The paper investigates E. coli strains from cancer patients with diarrhea, finding novel adherence patterns and high antibiotic resistance gene carriage.

Atg8-LC3 controls systemic nutrient surplus signaling from flies to humans.

This study identifies Atg8-LC3's role in leptin secretion across species, linking autophagy proteins to nutrient surplus signaling and organismal resilience.

Longitudinal host transcriptional responses to SARS-CoV-2 infection in adults with extremely high viral load

The paper examines longitudinal transcriptional responses to SARS-CoV-2 infection in adults with varying viral loads, identifying gene expression patterns and host responses over time.

Transcriptomic profiling reveals distinct subsets of immune checkpoint inhibitor-induced myositis

This study identifies three distinct transcriptomic subsets of immune checkpoint inhibitor-induced myositis using bulk and single-nuclei RNA sequencing.

Subtyping of Small Cell Lung Cancer using plasma cell-free nucleosomes

This study uses cfChIP-seq on plasma samples to subtype SCLC based on epigenetic states, linking plasma nucleosome data to tumor transcriptomes and developing a classifier for lineage-defining transcription factors.

Prediction of cancer treatment response from histopathology images through imputed transcriptomics

ENLIGHT-DeepPT predicts cancer treatment response from H&E slides by first imputing transcriptomics and then using that data to predict response across multiple therapies and cancer types.

Contrasting autoimmune and treatment effects reveals baseline set points of immune toxicity following checkpoint inhibitor treatment

The paper identifies pre-treatment immune signatures associated with immune-related adverse events (irAEs) in thymic cancer patients receiving checkpoint inhibitors using CITE-seq.

BRCA1 Hypermethylation In Sporadic Breast Cancers: Discovering A Novel Pathway To Tumorigenesis Via Coordinate NBR2 Deregulation And TNBC Transformation

This study identifies a novel pathway in sporadic breast cancers where BRCA1 hypermethylation leads to NBR2 deregulation, TNBC transformation, and aggressive tumor behavior through altered transcript ratios and hormone receptor dynamics.

The human nose organoid respiratory virus model: an ex-vivo human challenge model to study RSV and SARS-CoV-2 pathogenesis and evaluate therapeutics

This paper develops a non-invasive human nose organoid model to study RSV and SARS-CoV-2 infection and test therapeutics like palivizumab.

Effect of Substrate Stiffness on Human Intestinal Enteroids Infectivity by Enteroaggregative Escherichia coli

This study shows that substrate stiffness affects the adherence of EAEC bacteria to human intestinal enteroids, with softer hydrogels promoting larger bacterial aggregates.

Multiple RSV strains infecting HEp-2 and A549 cells reveal cell line-dependent differences in resistance to RSV infection.

The paper compares RSV infection in HEp-2 and A549 cells using four strains, finding subgroup-dependent gene expression differences and A549's greater antiviral response.

The structure of enteric human adenovirus 41 - a leading cause of diarrhoea in children

This study determines the structure of enteric HAdV-F41 using cryo-EM, revealing structural differences from non-enteric HAdVs that explain its tissue tropism and pathogenicity.

Oligonucleotide capture sequencing of the SARS-CoV-2 genome and subgenomic fragments from COVID-19 individuals

This study develops an oligonucleotide capture sequencing method to generate SARS-CoV-2 genomic and transcriptome sequences from clinical samples, revealing differential transcriptional activity and ORF10 expression.

Targeting of Mammalian Glycans Enhances Phage Predation in the Gastrointestinal Tract

This paper describes a phage that targets human glycans to enhance its activity in the gastrointestinal tract by positioning it near bacterial hosts.

Adipokines set neural tone by regulating synapse number

This paper shows that Upd2, a Drosophila Leptin ortholog, reduces inhibitory synaptic contacts on Insulin neurons, while Insulin increases synaptic contacts on its upstream inhibitory neurons, establishing energy-store-dependent neural tone.

Integrated proteogenomic analysis of metastatic thoracic tumors identifies APOBEC mutagenesis and copy number alterations as drivers of proteogenomic tumor evolution and heterogeneity