J. R. Clark

Spatial mapping reveals unique cellular interactions and enhanced tertiary lymphoid structures in responders to anti-PD-1 therapy in mucosal head and neck cancers.

The paper identifies immune landscape differences in responders and non-responders to anti-PD-1 therapy in head and neck cancers using spatial mapping.

Progress toward the development of an effective vaccine for Extraintestinal pathogenic E. coli (ExPEC): The application of the multiple-protein subunits vaccine in different murine models

This study evaluates pro-HlyA and Dual-Hit as vaccine candidates against ExPEC, showing reduced bacterial burden and increased survival in murine models.

High-dimensional and spatial analysis reveals immune landscape dependent progression in cutaneous squamous cell carcinoma

This study compares immune landscapes of non-progressing and progressing cutaneous squamous cell carcinomas to identify immune features associated with metastasis.

Phage resistance accompanies reduced fitness of uropathogenic E. coli in the urinary environment

This study shows that phage resistance in UPEC arises quickly in the urinary environment but comes with fitness costs that reduce bacterial growth and virulence.

Phage-Antibiotic Synergy Is Driven By A Unique Combination Of Antibacterial Mechanism Of Action And Stoichiometry

This paper investigates phage-antibiotic synergy by analyzing interactions across antibiotic classes and stoichiometries, finding that synergy depends on antibiotic mechanism, phage burst size, and host environment.

Targeting of Mammalian Glycans Enhances Phage Predation in the Gastrointestinal Tract

This paper describes a phage that targets human glycans to enhance its activity in the gastrointestinal tract by positioning it near bacterial hosts.

Zika virus replicates in skeletal muscle contributing to peripheral viral amplification prior to reach neural tissue

This study shows Zika virus replicates in skeletal muscle, contributing to peripheral viral amplification before reaching neural tissues.