The Atlas of the In Vivo HIV CD4 T Cell Reservoir
J. Neidleman, X. Luo, J. Frouard, G. Xie, F. Hsiao, T. Ma, V. Morcilla, A. Lee, S. Telwatte, R. Thomas, W. Tamaki, B. Wheeler, R. Hoh, P. Vohra, J. Milush, , N. R. Roan
The paper develops a method to trace latently-infected HIV CD4 T cells to their original states using CyTOF, revealing the reservoir's conserved yet tissue-specific composition and enabling isolation of unstimulated latent cells.
bioRxiv · Jun 27, 2020Immunology