W. Tamaki

Deciphering Cell-types and Gene Signatures Associated with Disease Activity in Rheumatoid Arthritis using Single Cell RNA-sequencing

This study uses single-cell RNA sequencing of PBMCs from RA patients and controls to identify disease-associated cell subsets and gene signatures linked to RA disease activity.

Myeloid-mesenchymal crosstalk drives Arg1-dependent profibrotic metabolism via ornithine in lung fibrosis

The paper identifies a myeloid-mesenchymal crosstalk pathway involving Arg1 and ornithine that drives profibrotic metabolism in lung fibrosis.

A focal adhesion kinase-YAP signaling axis drives drug tolerant persister cells and residual disease in lung cancer

This study identifies a FAK-YAP signaling axis that drives drug-tolerant persister cells and residual disease in lung cancer, showing that inhibiting this axis improves tumor response to targeted therapies.

Deep immune profiling reveals targetable mechanisms of immune evasion in checkpoint blockade-refractory glioblastoma

This study identifies immune evasion mechanisms in checkpoint blockade-refractory glioblastoma using deep immune profiling and shows that enhancing antigen presentation can improve immunotherapy response.

The Atlas of the In Vivo HIV CD4 T Cell Reservoir

The paper develops a method to trace latently-infected HIV CD4 T cells to their original states using CyTOF, revealing the reservoir's conserved yet tissue-specific composition and enabling isolation of unstimulated latent cells.