N. R. Roan

Plasma Glycomic Markers of Accelerated Biological Aging During Chronic HIV Infection

This study identifies glycomic alterations in HIV-positive individuals that correlate with accelerated aging and comorbidities, suggesting potential biomarkers for early detection.

Post-acute immunological and behavioral sequelae in mice after Omicron infection

This study investigates post-acute immunological and behavioral effects in mice after Omicron infection, showing vaccination reduces pulmonary immune perturbations and behavioral deficits.

Long COVID manifests with T cell dysregulation, inflammation, and an uncoordinated adaptive immune response to SARS-CoV-2

This study identifies T cell dysregulation, inflammation, and mis-coordinated adaptive immune responses in Long COVID patients compared to non-LC individuals.

The Hypoxia-regulated Ectonucleotidase CD73 is a Host Determinant of HIV Latency

This study identifies CD73 as a marker of HIV latency, showing hypoxia enhances its expression and adenosine signaling promotes viral quiescence.

CyTOF-Lec: Single-cell glycomics analysis reveals glycan features defining cells differentially susceptible to HIV

This study develops CyTOF-Lec to analyze glycan features in human immune cells, revealing that sialic acid levels distinguish HIV-susceptible memory CD4+ T cells.

Deep Immunophenotyping Reveals Endometriosis is Marked by Dysregulation of the Mononuclear Phagocytic System in Endometrium and Peripheral Blood

This study uses mass cytometry to analyze immune cell phenotypes in endometriosis patients, finding dysregulated mononuclear phagocytic system in endometrium and blood.

Deep Phenotypic Analysis of Blood and Lymphoid T and NK Cells from HIV+ Controllers and Non-Controllers

This study compares T and NK cell phenotypes in blood and lymph nodes of HIV+ controllers and ART-treated individuals, finding distinct cellular features in lymphoid tissues.

mRNA vaccine-induced T cells respond identically to SARS-CoV-2 variants of concern but differ in longevity and homing properties depending on prior infection status

The CCL2 Chemokine Promotes Early Seeding of the Latent HIV Reservoir

This study shows that CCL2 chemokine promotes early HIV reservoir formation by recruiting CCR2/5+ CD4 T cells to sites of inflammation during acute infection.

The Atlas of the In Vivo HIV CD4 T Cell Reservoir

The paper develops a method to trace latently-infected HIV CD4 T cells to their original states using CyTOF, revealing the reservoir's conserved yet tissue-specific composition and enabling isolation of unstimulated latent cells.

SARS-CoV-2-specific T cells exhibit unique features reflecting robust helper function, lack of terminal differentiation, and high proliferative potential

The paper characterizes SARS-CoV-2-specific T cells in recovered patients, finding they exhibit robust helper function, reduced terminal differentiation, and high proliferative potential.