Vaccine-induced antibodies are sufficient to limit Salmonella infection in the absence of complement or macrophages.
Marisol Pérez-Toledo, Kubra Aksu-Istil, Edith Marcial‐Juárez, Ruby Persaud, Areej Alshayea, Siân E. Jossi, Agostina Carestia, Fien A. von Meijenfeldt, Marina Botto, Leo C. James, Baas Sureward, William G. C. Horsnell, Constantino III Roberto López-Macías, Ian R. Henderson, Craig N. Jenne, Adam F. Cunningham
This study shows that antibodies alone can limit Salmonella infection, but their effectiveness is enhanced by complement and macrophages.
bioRxiv · Aug 27, 2025 · PreprintImmunology