Discovery of compounds targeting human acute myeloid leukemia stem cells via a novel high-throughput screen
Isabella Angela Iasenza, Safia Safa-Tahar-Henni, Hassan Dakik, Manon Saby, Bahareh Jafari, Patricia Arreba-Tutusaus, Meaghan Boileau, Andrea L. Neumann, Josée Hébert, Sonia Cellot, Frédéric Barabé, Brian T. Wilhelm, Kolja Eppert
This study identifies compounds targeting human AML stem cells through a high-throughput screen and validates their efficacy using xenotransplantation and single-cell RNA sequencing.
bioRxiv · Sep 10, 2026 · PreprintCancer Biology