Interplay between the cyclophilin homology domain of RANBP2 and MX2 regulates HIV-1 capsid dependencies on nucleoporins
Haley Flick, Ananya Venbakkam, Parmit Kumar Singh, Bailey Layish, S.-W. K. Huang, Rajalingam Radhakrishnan, Mamuka Kvaratskhelia, A. N. Engelman, Melissa Kane
This study shows that the RANBP2-Cyp domain influences HIV-1 infection and MX2 activity by modulating CA interactions with nucleoporins and integration targeting.
mBio · Jan 24, 2025Peer-reviewedMicrobiology