Author

Melissa Kane

University of PittsburghORCID 0000-0002-4580-1210Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:proteomics· 1 Research Focus:variant calling· 1

Frequent Co-Authors

A. N. EngelmaniD· 2 shared Ashley Willey· 2 shared Brady Callahan· 2 shared Lia Robben· 2 shared Parmit Kumar SinghiD· 2 shared Robert Z. ZhangiD· 2 shared Sandra Umana· 2 shared Vincent Mele· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersMicrobiology

A. N. EngelmanORCID

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4 papers

Recent·Most cited

Determinants in gammaretroviral Env dictate the production of neutralizing antibodies

Robert Z. Zhang, Lia Robben, Ashley Willey, Vincent Mele, Emilia Crow, Sandra Umana, Brady Callahan, Laura Arroyo, Grace W. Graudin, Holly C. Simmons, Kevin R. McCarthy, Melissa Kane

This study identifies viral determinants that influence neutralizing antibody production through a noncanonical pathway in gammaretroviral infections.

bioRxiv · Aug 4, 2026 · PreprintImmunology

TLR7-independent control of retroviral infection

Robert Z. Zhang, Lia Robben, Ashley Willey, Sandra Umana, Vincent Mele, Brady Callahan, Tatyana V. Golovkina, Melissa Kane

The paper shows that mice can control retroviral infection without TLR7 signaling, suggesting an alternative sensing pathway for immune activation.

bioRxiv · Apr 29, 2026 · PreprintMicrobiology

Spatiotemporal binding of cyclophilin A and CPSF6 to capsid regulates HIV-1 nuclear entry and integration

Zachary Ingram, Christopher E. Kline, Alexandra K. Hughson, Parmit Kumar Singh, Hannah L. Fischer, Rajalingham Radhakrishnan, Gregory A. Sowd, Nayara F. B. dos Santos, Barbie K. Ganser‐Pornillos, Simon C. Watkins, Melissa Kane, A. N. Engelman, Zandrea Ambrose

This study shows that sequential binding of CypA and CPSF6 to HIV-1 capsid is necessary for nuclear entry and integration, and that lenacapavir targets this process.

mBio · Feb 27, 2025Peer-reviewedMicrobiology

Interplay between the cyclophilin homology domain of RANBP2 and MX2 regulates HIV-1 capsid dependencies on nucleoporins

Haley Flick, Ananya Venbakkam, Parmit Kumar Singh, Bailey Layish, S.-W. K. Huang, Rajalingam Radhakrishnan, Mamuka Kvaratskhelia, A. N. Engelman, Melissa Kane

This study shows that the RANBP2-Cyp domain influences HIV-1 infection and MX2 activity by modulating CA interactions with nucleoporins and integration targeting.

mBio · Jan 24, 2025Peer-reviewedMicrobiology