SOD1 activity thresholds and TOR signalling modulate VAP(P58S) aggregation via ROS-induced proteasomal degradation in a Drosophila model of Amyotrophic Lateral Sclerosis
Kriti Chaplot, Lokesh G. Pimpale, Balaji Ramalingam, Senthilkumar Deivasigamani, Siddhesh S. Kamat, Girish S. Ratnaparkhi
The paper identifies SOD1, TOR signaling, and ROS as modifiers of VAP(P58S) aggregation in a Drosophila ALS model, showing proteasomal clearance via ROS-induced degradation.
Disease Models & Mechanisms · Jan 1, 2019Peer-reviewedNeuroscience