Girish S. Ratnaparkhi

This study identifies lipid imbalance in a Drosophila ALS8 model, showing that VAPB activity regulates lipid homeostasis in neurons and glia.

The paper shows that Wunen(s) inhibit Hedgehog signaling in Drosophila PGCs by affecting Smo localization and lipid metabolism, preventing premature clumping.

The paper identifies Fos as a regulator of age-dependent neuroinflammation in a Drosophila model of ALS8, showing its role in modulating inflammation and motor function.

This study shows that glial ceramide production and transfer are essential for lipid droplet homeostasis and motor function in Drosophila, with implications for motor neuron diseases.

The paper identifies Mon1 as a key regulator of oskar mRNA localization and axial patterning in oocytes, showing both cell autonomous and non-cell autonomous roles.

The paper assesses the replicability of claims in Drosophila immunity research by analyzing 400 publications and identifying contradictory evidence.

The paper identifies sequence determinants of ABHD12 enzymatic activity through bioinformatics and biochemical validation, and identifies a Drosophila ortholog with lyso-PS lipase activity.

This study investigates the role of Caspar in Drosophila melanogaster, showing it regulates primordial germ cell count and identity through interactions with Smaug and effects on Oskar protein levels.

This study investigates age-dependent changes in neuronal VAPBALS inclusions in a Drosophila ALS model, showing autophagy's role in aggregate clearance and the impact of TER94 on inclusion density.

This study shows that SUMOylation of Jra in Drosophila modulates the gut immune response to Pseudomonas entomophila by regulating gene expression and immune signaling.

This study shows SUMOylation of Dorsal reduces its transcriptional activation, enhancing robustness in development and immune response.

The paper shows that Caspar overexpression in glia slows ALS progression by reducing inflammation in a Drosophila model.

This study investigates the role of Dmon1 and Rab7 in regulating GluRIIA levels at the Drosophila neuromuscular junction, showing their interaction in the endo-lysosomal pathway.

The paper identifies DMon1 as a novel regulator in the brain-gonad axis, showing its role in female germline maturation through neuronal control of insulin production.

The paper identifies SOD1, TOR signaling, and ROS as modifiers of VAP(P58S) aggregation in a Drosophila ALS model, showing proteasomal clearance via ROS-induced degradation.