Siddhesh S. Kamat

This study identifies lipoprotein lipase (LPL) as a neutral cholesteryl ester hydrolase in mammals through biochemical and pharmacological analyses.

This study uses three orthogonal chemical proteomic strategies to identify 495 cholesteryl ester-associated proteins in mammalian cells, revealing their functional and disease relevance.

This study identifies lysosomal acid lipase (LIPA) as a key enzyme regulating cholesterol metabolism during phagosomal maturation, linking lipid catabolism to antimicrobial defense.

This study identifies a VDR-independent mineralization pathway in osteoblasts induced by γ-linolenic acid through the CaMKII-SMAD2/3 pathway, offering a metabolic strategy to restore bone formation under vitamin D deficiency.

This study identifies lipid imbalance in a Drosophila ALS8 model, showing that VAPB activity regulates lipid homeostasis in neurons and glia.

This study identifies a Dip2-mediated Pkc1 signalling axis regulated by specific DAGs that maintains mitochondrial integrity in yeast.

This study functionally characterizes ABHD14A, showing it is an active enzyme with specific substrate preferences and subcellular localization, and provides tools for further research.

The paper shows that Wunen(s) inhibit Hedgehog signaling in Drosophila PGCs by affecting Smo localization and lipid metabolism, preventing premature clumping.

This study shows LSD1 regulates host alpha-ketoglutarate levels, modulating lipid peroxidation and mycobacterial survival during tuberculosis infection.

This study identifies P7-Pen as a peptide that enhances monocyte inflammatory responses in sepsis by modulating histone acetylation through ABHD14B.

This study identifies a metabolic hierarchy in Caulobacter crescentus that coordinates cell cycle transitions and morphogenesis through redox dynamics.

The paper shows that targeting kinesin-1 on lipid droplets reduces serum lipids in cell culture and zebrafish, with no toxicity or lipid accumulation.

The paper identifies shared and sex-specific lipidomic changes in brain and plasma of Parkinson's disease models and patients, showing peripheral lipid signatures reflect CNS pathology.

This study identifies PE11 as a factor that promotes Mtb persistence by inhibiting autophagy and lysosomal biogenesis through the FLCN-lactate-TFEB signaling axis, with lactate shown to enhance bacterial clearance.

The paper identifies protein ligands for monoacylglycerol lipids using chemical proteomics in mouse brain and cell lysates, revealing Hippocalcin as a novel ligand involved in calcium sensing.

This study identifies Wag31's role in lipid homeostasis in mycobacteria by showing its tethering activity and interactions with membrane proteins.

The paper identifies Dip2 as a conserved regulator of DAG-based PKC signaling in eukaryotes, showing its role in maintaining specific DAG subpopulations required for PKC-mediated pathways.

The paper identifies sequence determinants of ABHD12 enzymatic activity through bioinformatics and biochemical validation, and identifies a Drosophila ortholog with lyso-PS lipase activity.

This study identifies mTOR-dependent macropinocytosis in zebrafish periderm as a nutrient acquisition mechanism during epidermal development.

The paper identifies ABHD6 as a lyso-PS lipase in the liver and kidneys, validating its enzymatic activity in vitro and in vivo.

This study develops an in vitro platform to investigate macrophage recruitment to breast cancer spheroids and their impact on spheroid behavior.

This study shows statins target SATB family proteins in the Wnt/β-catenin pathway, altering their expression and supporting their potential as anti-cancer agents in colorectal cancer.

The paper develops a reverse-phase LC-MS method to profile cholesterol and cholesteryl esters in mammalian cells and tissues, revealing their monounsaturated and polyunsaturated variants.

This study shows Mtb induces PPARγ in hepatocytes to create lipid droplets and drug-tolerant environments, contributing to systemic pathogenicity and metabolic impairments during TB infection.

The paper shows that Shh's morphogenic and mitogenic roles are segregated on distinct exosomal pools regulated by Rab7 levels during spinal cord development.

This study shows that loss of ABHD12 enzymatic activity increases phagocytosis in cerebellar microglia, leading to neuroinflammation in a mouse model of PHARC.

The paper identifies SOD1, TOR signaling, and ROS as modifiers of VAP(P58S) aggregation in a Drosophila ALS model, showing proteasomal clearance via ROS-induced degradation.