Lokesh G. Pimpale

The paper shows that reversing active chiral torques in C. elegans leads to mirrored embryos and situs inversus, demonstrating their role in determining body plan handedness.

The paper shows that cortical pulling forces misalign the mitotic spindle with the cell's long axis, but an actomyosin-based cell rotation corrects this, aligning the spindle with the long axis, thus fulfilling Hertwig's rule.

This paper develops a multi-chamber cardioid platform to study human heart development and defects by generating compartment-specific gene expression, morphology, and function.

The paper shows CYK-1/Formin activation in RhoA foci generates active torque in the actomyosin cortex, driving chiral counter-rotation and left-right symmetry breaking in C. elegans embryos.

The paper shows that during insect gastrulation, regionalized tissue fluidization by an actomyosin cable enables epithelial gap closure through cell intercalation and tension release.

The paper identifies SOD1, TOR signaling, and ROS as modifiers of VAP(P58S) aggregation in a Drosophila ALS model, showing proteasomal clearance via ROS-induced degradation.