Structural evolution of a yeast amyloid in vivo is shaped by chaperones
Z.P. Wang, Samantha L. Weetman, Barbara Altenhuber, Alexey G. Murzin, James D. Gilbert, Riccardo Zenezini Chiozzi, Nadejda Koloteva‐Levine, Helen R. Saibil, John Collinge, Mick F. Tuite, Wei‐Feng Xue, Wenjuan Zhang
This study shows that chaperones shape the structural evolution of yeast prion amyloids during maturation, with Hsp104 inhibiting structural diversity.
bioRxiv · Aug 11, 2026 · PreprintMolecular Biology